Dutch health economic guidelines include a costing manual, which describes preferred research methodology for costing studies and reference prices to ensure high quality studies and comparability between study outcomes.This paper describes the most important revisions of the costing manual compared to the previous version.An online survey was sent
ObjectiveTo simplify the ship modeling process and improve modeling efficiency, this paper proposes a method for rapidly implementing hull model creation based on hull line drawing.MethodsUsing the CATIA platform, this method adopts the component application architecture (CAA) development tool for secondary development.First, by reading the geometr
RNA methylation is a novel epigenetic modification that can be used to evaluate tumor prognosis.However, the underlying mechanisms are unclear.This study aimed to investigate the genetic characteristics of 5-methylcytosine (m5C) and N1-methyladenosine (m1A) regulators in lung squamous cell carcinoma (LUSC) and the prognostic value and immune-relate
It was previously believed that the long-term persistent increase in the spin-down rate of the Crab pulsar following a glitch is direct evidence of a starquake-induced glitch or at least related to a starquake.Using radio data covering 1710 days following the 2017 glitch, we obtain an extreme persistent increase of the spin-down rate, which allows
Background and purpose: Life and death became significant issues with the outbreak of the COVID-19 and its aftermath.Previous studies have shown that having meaning in life and the ability to regulate emotion can play effective roles in coping with death anxiety.The present study investigated the relationship between COVID-19 anxiety and death anxi